Background: Data on clinical characteristics and outcomes in regard to hip fracture (HF) type are controversial.\r\nThis study aimed to evaluate whether clinical and laboratory predictors of poorer outcomes differ by HF type.\r\nMethods: Prospective evaluation of 761 consecutively admitted patients (mean age 82.3 �± 8.8 years; 74.9%\r\nwomen) with low-trauma non-pathological HF. Clinical characteristics and short-term outcomes were recorded.\r\nHaematological, renal, liver and thyroid status, C-reactive protein, cardiac troponin I, serum 25(OH) vitamin D, PTH,\r\nleptin, adiponectin and resistin were determined.\r\nResults: The cervical compared to the tronchanteric HF group was younger, have higher mean haemoglobin,\r\nalbumin, adiponectin and resistin and lower PTH levels (all P < 0.05). In-hospital mortality, length of hospital stay\r\n(LOS), incidence of post-operative myocardial injury and need of institutionalisation were similar in both groups.\r\nMultivariate analysis revealed as independent predictors for in-hospital death in patient with cervical HF male sex,\r\nhyperparathyroidism and lower leptin levels, while in patients with trochanteric HF only hyperparathyroidism; for\r\npost-operative myocardial injury dementia, smoking and renal impairment in the former group and coronary artery\r\ndisease (CAD), hyperparathyroidism and hypoleptinaemia in the latter; for LOS > 20 days CAD, and age > 75 years\r\nand hyperparathyroidism, respectively. Need of institutionalisation was predicted by age > 75 years and dementia\r\nin both groups and also by hypovitaminosis D in the cervical and by hyperparathyroidism in the trochanteric HF.\r\nConclusions: Clinical characteristics and incidence of poorer short-term outcomes in the two main HF types are\r\nrather similar but risk factors for certain outcomes are site-specific reflecting differences in underlying mechanisms.
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